Rishov Mukhopadhyay

Development of TRIM-specific assays suitable for High- Throughput- Screening

Host Lab

LUMC - Academisch Ziekenhuis Leiden
Leiden University Medical Center - Dept. of Chemical Immunology


Rishov obtained a Bachelor’s degree in Pharmaceutical Sciences from Jadavpur University, India in 2014. He was awarded the First class first and the University Gold Medal. Following this he has worked at a multinational cosmetic company as a Quality Control Chemist till 2016. Then, he moved to the University of Nottingham in the United Kingdom to pursue master’s education on Drug Discovery and Pharmaceutical Sciences. He was awarded the MSc. in 2017. Subsequently, he worked with a  startup medical device company in the U.K. as a Regulatory Affairs intern.  During bachelor’s studies, Rishov was involved in identification and characterization of natural compounds of Ethno-pharmacological importance. His interest in chemical biology developed during master’s education where he was fascinated by the diverse behavior of Ubiquitin Proteasome System. His work mostly focused upon understanding the interaction of Ubiquitin Specific Protease (USP15) with its inhibitor Mitoxantrone based on crystallographic studies.

Rishov has joined the laboratory of Prof. Huib Ovaa to pursue Ph.D. in Chemical Immunology. He has been accepted under the ESR Marie Skłodowska-Curie ITN: TRIM-NET project. His Ph.D. work is focused upon developing appropriate high-throughput assays for Tri-Partite Motif (TRIM) proteins. The work encompasses developing recombinant E2 and E3 proteins. Following this, the  focus will be put on assay development and validation for translation towards high throughput screening. This effort will also include the generation of assay reagents and/or synthetic peptide substrates by total synthesis.